For today’s tip, I would like to introduce you to the TDR Targets Database, which seeks “… to exploit the availability of diverse datasets to facilitate the identification and prioritization of drug targets in pathogens causing neglected diseases.” I found out about this database this past weekend as I was catching up on my ‘science reading’. The database was featured in an article published November of 2008 in Nature Reviews Drug Discover – if you have a subscription, I’ve cited it below. Even though the article is a bit old, it seems very timely for us here at OpenHelix right now since in February Trey participated in the first annual African Virtual Conference on Bioinformatics 2009, and later this week he is heading off to give a talk at the Genetics and Genomics of Infectious Diseases conference in Singapore. TDR Targets is a nice resource – here I show a few search options, but there is so much more here that you can explore on your own!
Agüero, F., Al-Lazikani, B., Aslett, M., Berriman, M., Buckner, F., Campbell, R., Carmona, S., Carruthers, I., Chan, A., Chen, F., Crowther, G., Doyle, M., Hertz-Fowler, C., Hopkins, A., McAllister, G., Nwaka, S., Overington, J., Pain, A., Paolini, G., Pieper, U., Ralph, S., Riechers, A., Roos, D., Sali, A., Shanmugam, D., Suzuki, T., Van Voorhis, W., & Verlinde, C. (2008). Genomic-scale prioritization of drug targets: the TDR Targets database Nature Reviews Drug Discovery, 7 (11), 900-907 DOI: 10.1038/nrd2684