Reactome is one of our favorite tools to explore pathways. And they cover a wide range of species, which is helpful for many researchers. But there are times when having a topic-specific tool can be even more useful for a research community. Sometimes these types of tools are disease-specific, or in the case of today’s Video Tip of the Week, plant-centric. If you haven’t seen it before, this introduction to Plant Reactome is worth exploring.
In this overview of Plant Reactome, Justin Preece describes the data model to help understand the foundation of Reactome. And then quickly moves into how you can access this tool from the Gramene portal. There’s guidance on the organization of the interface, and how to access pathways you are interested in. Then there’s an explanation of their process of projecting pathways from well-characterized rice data on to other species that might be less well characterized. They have over 200 curated rice pathways and ongoing curation as well. There are dozens of Arabidopsis curated pathways too. There’s a bit about the move to the new Reactome platform, and analysis tools available with that. There’s an example of time course data shown to illustrate a series of data. The talk touches a little bit on the new main Reactome interface that we also highlighted.
Try it out.
Plant Reactome directly: http://plantreactome.gramene.org/
Gramene main site: http://www.gramene.org/
Tello-Ruiz, M., Stein, J., Wei, S., Preece, J., Olson, A., Naithani, S., Amarasinghe, V., Dharmawardhana, P., Jiao, Y., Mulvaney, J., Kumari, S., Chougule, K., Elser, J., Wang, B., Thomason, J., Bolser, D., Kerhornou, A., Walts, B., Fonseca, N., Huerta, L., Keays, M., Tang, Y., Parkinson, H., Fabregat, A., McKay, S., Weiser, J., D’Eustachio, P., Stein, L., Petryszak, R., Kersey, P., Jaiswal, P., & Ware, D. (2015). Gramene 2016: comparative plant genomics and pathway resources Nucleic Acids Research DOI: 10.1093/nar/gkv1179
Fabregat, A., Sidiropoulos, K., Garapati, P., Gillespie, M., Hausmann, K., Haw, R., Jassal, B., Jupe, S., Korninger, F., McKay, S., Matthews, L., May, B., Milacic, M., Rothfels, K., Shamovsky, V., Webber, M., Weiser, J., Williams, M., Wu, G., Stein, L., Hermjakob, H., & D’Eustachio, P. (2015). The Reactome pathway Knowledgebase Nucleic Acids Research DOI: 10.1093/nar/gkv1351