标记档案: 模式生物


一周的视频提示: 电视空军基地, 并支持模式生物群落的一封信

本周的视频技巧是两件事情提示. 第一, it was a tweet from FlyBase, 他们的视频频道. It’s been a while since we’d done a FlyBase Tip of the Week, so that was enough of a reason.

But it also came just after I was thinking about the importance of the model organisms, based on the campaign by the model organism databases to save their funding. Here’s a tweet from the yeast genome database (新元) with a plea:

But this letter cites yeast, 苍蝇, WormBase, 舞蹈, 麦肯锡, 含RGD基因本体论 以及.

mergeI have a soft spot for model organisms, not only because of the tremendous amount of great biology they’ve provided. I was a postdoc at The Jackson Lab, and I am acutely aware of how crucial it is to have the depth of the species specialists involved in creating and maintaining the resources that are appropriate for their organism. But it’s more than just institutional knowledge and data, 当然. It’s also the importance of the community of researchers working on that organism, supporting them and having their needs met in many ways with species-specific resources.

So this week’s tip highlights some features of the FlyBase tools, as a way to remind folks of the great work that’s going on at model organism databases (MODs).

现在, if you haven’t already done so, please consider signing on to the letter of support for these databases. You can read more about the issue over at the site, but briefly:

NHGRI/NIH has recently advanced a plan in which the MODs will be integrated into a single combined database, along with a 30% reduction in funding for each MOD (see also these 自然科学 news stories). While increased integration will present many advantages, the plan will result in a loss of critical organism-specific datasets. The funding cut will also cripple core functions such as high quality literature curation and genome annotation, degrading the utility of the MODs. Given the large number of scientists that this policy change would affect and the importance of their work, this is a matter of extreme concern.

I have always shouted about the importance of high-quality curation. It’s so undervalued, but it’s only more and more crucial now that we are getting so much sequence data and we need the best existing knowledge to help guide us through it. Now is not the time to cut back on curation.

So if you have valued MOD data and community sites, please consider signing on to the letter of support.


FlyBase: http://flybase.org/

Support Model Organism Databases 信: http://www.genetics-gsa.org/MODSupport/


海登, Erica Check. “Funding for model-organism databases in trouble.” 自然新闻. () 分类号: 10.1038/nature.2016.20134

凯撒, Jocelyn. “Funding for key data resources in jeopardy.” 科学 351.6268 (2016): 14-14. 分类号: 10.1126/science.351.6268.14

Attrill, Helen, 等. “FlyBase: establishing a Gene Group resource for Drosophila melanogaster.” 核酸研究 (2015): gkv1046. 分类号: 10.1093/nar/gkv1046


OpenHelix今天宣布对模式生物数据库和广泛的资源用于研究的教程免费提供套房. 第一个教程套房可用GBrowse, 大鼠基因组数据库 (含RGD), 小鼠基因组信息学 (麦肯锡), 和WormBase. 要在未来几周内添加的斑马鱼信息网 (舞蹈), FlyBase和酿酒 (酵母) 基因组数据库 (新元).

本教程套房, 部分资金由美国国立卫生研究院国家人类基因组研究所的赠款, 包括自我运行, 解说的教程,介绍资源,以及如何使用其功能和职能. 每个套件还包括PowerPoint幻灯片, 讲义, 可作参考或用于培训他人的演习.

其中一个可用的第一个教程是关于GBrowse, 开发的通用模式生物数据库 (全球媒体点播) 项目, 研究人员使用一种流行的工具,发展模式生物的基因组浏览器, 种利益, 特定主题. 通过学习如何使用这个“通用”的基因组浏览器, 你可以充分利用这些知识来使用专门的研究领域的广泛资源的几十.

“OpenHelix GBrowse用户教程做得非常好,许多研究使用GBrowse基因组数据的可视化社区将是一个极好的资源,“戴夫说,克莱门茨的国家进化综合中心运行GMOD帮助台.

模式生物, 如酵母, 鼠标, 大鼠, 苍蝇, 和许多其他, 研究人员,以扩大我们理解生物学和疗法的有效性和安全性评估人体试验之前早已习惯. 这些微生物的基因组中的许多人都被完全测序, 科学界给予更大的洞察到生物体及其与人类生物学. 基因组数据,现在可以公开在网上提供数据库和资源搜索.

您可以查看模式生物教程 銈://www.openhelix.com / model_organisms.shtml. OpenHelix提供超过 60 其他教程套房在一个基因组数据库和资源的数量,通过个人, 组, 或机构认购. 进一步的信息可以发现在www.openhelix.com.

OpenHelix, 有限责任公司, (www.openhelix.com) 提供基因组学知识,你需要的时候你需要它. OpenHelix提供网上自学教程运行和现场培训的机构和企业的最强大和最流行的免费, 基于网络, 公开访问的生物信息学资源. 此外, OpenHelix资源提供者签订合约,提供全面的, 长期的培训和推广计划.

新的网上教程上FlyBase, WormBase和小鼠基因组信息学 (麦肯锡) 资源

对模式生物的生物信息学数据库FlyBase综合教程, WormBase和麦肯锡全球研究院的研究人员能够迅速和有效地利用这些宝贵资源.

OpenHelix 今天宣布几种模式生物资源,包括FlyBase新教程套房可用性, WormBase和对小鼠基因组信息的更新 (麦肯锡) 数据库. 模式生物是必不可少的基础生物学和现代生物医学科研的认识. 果蝇, ç. 线虫和小鼠研究模式生物三个高度. FlyBaseWormBase 对于分子和遗传上的果蝇和线虫的信息和相关物种的主要资源, 分别. 麦肯锡 是一套工具和数据库集成的一系列遗传学, 基因组学和生物学的实验小鼠.

本教程套房, 适用于单一购买或通过一个低价格每年订阅所有OpenHelix教程, 包含一个叙述, 自营, 在线教程, 幻灯片, 讲义和练习. 随着教程, 研究人员可以很快学会有效地使用这些资源. 这些教程将教用户:

  • 进行快速搜索和导航基因摘要页面
  • 浏览整个范围内的染色体中遗传特征
  • 构建跨各种数据存储在FlyBase套​​复杂的查询, WormBase或最低收入保障
  • 执行核苷酸或者氨基酸序列的同源性搜索
  • 各种格式输出数据, 或访问大量数据的报告
  • 调查与最低收入保障有关的许多相关资源

要了解有关这些和其他教程套房详情,请访问 OpenHelix.