1,000 dollars to sequence the entire 3 billion ‘basepair’ long human genome is the holy grail. Last year, on this blog, I predicted that we’d reach that goal ‘within a year’. Well, it’s been a year and we aren’t there. I did hedge a bit in the comments later, but the main point was that the cost was plummeting and headed for $1,000 for an entire genome. The graph at the left is cost of a single genome from 2003 to 2010… 300 million, to 10 thousand.
The cost is still plummeting. Illumina* has lowered the cost of sequencing the genome to $5,000. Half.Complete Genomics* today announced that their first quarter revenue was 6.8 million, up from 300 thousand last year. They have 2,000 complete genomes to sequence in their backlog. They charge < 10,000 for small orders, down to $5,000 for bulk orders (in research groups). The cost of sequencing large groups for research is getting much smaller.
So the price plummets still.
The price for genomic scans also plummets. 23andMe, which scans about 1 million variable sites in your genome (most of the human genome is not variable from person to person), cost 400 dollars last year, in December they price went to 200. After a one-day free sale, it’s now $100.
Of course, the question remains how expensive will it be to analyze that data.
*full disclosure, I own a (very) small amount of stock in both Illumina and Complete Genomics.
Welcome to our Friday feature link collection: SNPpets. During the week we come across a lot of links and reads that we think are interesting, but don’t make it to a blog post. Here they are for your enjoyment…
- Shout out to Daniel MacArthur and Paul D. who sought us out at ASHG to say hello. It was great to meet you guys. [Mary]
- While I was away last week an update email came from DGV–Database of Genome Variants. They alert us to this: “The Database of Genomic Variants (DGV) has just been updated, with data added from four new studies. A total of 12,497 new variants have been added, including data from the HapMap III Consortium.” And you can learn more in their newsletter (a PDF). [Mary]
- Best Captcha evah (as Mary would say) [Trey]
- The PDB mailing list had an email from Dan Bolser, who is creating a list of BioWikis: http://nettab.referata.com/wiki/BioWiki [Mary]
- Complete Genomics didn’t get the 12-14 price they projected (9 instead) in their IPO, I think it had to do with the press personal genomics is getting, not the company [Trey]
- On a somewhat related not to CG above, interesting post from Genomics Law Report: sequencing for thousands, suing for millions. [Trey]
- I knew science could be tough, but I had no idea it was this bad off: Undergraduate Science: Better Intro Courses Seen as Key to Reducing Attrition of STEM Majors [Jennifer]
- I liked this example of a cool model for epigenomics studies: Honey Bees: Genetic Labeling Decides About Blue Blood [Mary]
- Also stopping by the booth was Dr. Digamber Borgaonkar, the founder of the Chromosomal Variation in Man literature database. Thanks for mentioning it! [Mary]
- Tweet of the week: @rich_: Going to start a rad new field: a systems approach to comp.genomics and phenomics. It shall be called “biology”. #wrongsideofbed [Mary]
Genetic Future reports: First ever association study using whole genome sequences.
New-technology DNA sequencing provider Complete Genomics will provide near-complete genome sequences of 100 individuals to the Institute for Systems Biology, driving the first ever association study for a complex trait using whole-genome sequencing. Here’s the press release, and GenomeWeb has some additional information
This study was done by Complete Genomics, and as Daniel mentions, does indicate some changes and advances to come. Read the entire post, he mentions some things learned at ASHG about how these studies will look in the future, and particularly, this sentence…
Now the real challenge - coming up with ways of handling the massive volumes of data generated by these technologies
goes to the heart of something I see as a very important question. Not only the right tools but funding them.
An embarrassment of riches.
I was just having this discussion with in-laws, both in the medical field, that personal genomics was on it’s way. We discussed how this was going to affect our health insurance and health care, in both good and scary ways. Well, as Genetic Future blogs, Illumina delivers its first commercial personal genome sequence.
The service cost 48,000 US dollars, which is of course a far cry from the millions it would have cost a decade ago. Complete Genomics, a new company to do just this, says it will offer genome sequences for 5k US dollars. So pricing will only go down all around as competition heats up.
That light you see might be the train of personal genomics.