“What’s the Answer”

BioStar is a site for asking, answering and discussing bioinformatics question

s. We are members of the community and find it very useful. Often questions and answers arise at BioStar that are germane to our readers (end users of genomics resources). Every Thursday we will be highlighting one of those questions and answers here in this thread. You can ask questions in this thread, or you can always join in at BioStar.

Today’s question and answer is:

What is the best resource for Protein/Genetic interactions?

One of several answers:

Protein interactions: If you are interested primary in protein interactions, look first at the IMEx consortium; all of the databases that you mention are a part of it. Their interactions are available through PSICQUIC web services, described here: http://code.google.com/p/psicquic/

Some websites combine data from multiple molecular interaction databases, e.g., Pathway Commonsand IRefWeb. I know you can download a combined dataset of interactions from Pathway Commons but I haven’t tried doing this with IRefWeb.

Genetic interactions: I think that BioGRID is the only major database that currently curates genetic interactions.