Tip of the week: SNPs on Protein Structure

The wealth of SNP data we are seeing these days is providing major insights into inheritance, population frequencies, effects on regulatory regions, splice sites and–of course–coding regions. Coding non-synonymous SNPs change the amino acid sequence of a protein. To get a sense of what that means on the protein structure you could use the GeneSNPs resource. We have a complete tutorial on GeneSNPs that you could watch. But to get a taste of how this data can be presented I’m going to show you a quick example of a SNP that changes an amino acid sequence on a protein structure. This is done with the PDBViewer tools at GeneSNPs. It requires MDL® Chime software for your browser. It is great to visualize the changes and think about what happens on your proteins of interest.