The wealth of SNP data we are seeing these days is providing major insights into inheritance, population frequencies, effects on regulatory regions, splice sites and–of course–coding regions. Coding non-synonymous SNPs change the amino acid sequence of a protein. To get a sense of what that means on the protein structure you could use the GeneSNPs resource. We have a complete tutorial on GeneSNPs that you could watch. But to get a taste of how this data can be presented I’m going to show you a quick example of a SNP that changes an amino acid sequence on a protein structure. This is done with the PDBViewer tools at GeneSNPs. It requires MDL® Chime software for your browser. It is great to visualize the changes and think about what happens on your proteins of interest.