This morning my BioSmart Brief had a quick note about another genome (yes, another day, another genome…) Penicillium chrysogenum. This one caught my eye because just yesterday I had found a really neat resource about penicillin.
The link is to a BBC article about the project: Penicillin bug genome unravelled
The paper from van den Berg et al is here in Nature Biotechnology: Genome sequencing and analysis of the filamentous fungus Penicillium chrysogenum
The reason that it caught my eye was because just yesterday I found the section of KEGG that includes the History of Drug Development. I didn’t even know they had such a section–but from the KEGG Drug interface you can find that feature. From there you can link to pathways of drug development for a variety of compounds. Here’s the link the the penicillin history pathway. I found it fascinating to think about. From there you can also link back to the genetic pathway that produces penicillin by clicking the bubble for Penicillin and cephalosporin biosynthesis.
The image I show is just a portion of the history pathway from KEGG. Check it out–fascinating stuff.