At first the title of this paper made laugh, as I am a major fan of Paul Scofield’s performance in A Man for All Seasons. And then I remembered what happened to Thomas More. Well, the analogy drops away for me there…. A Mouse for All Reasons by the International Mouse Knockout Consortium presented the framework and foundations of the project to knock out every single protein-coding gene in mice, generate the corresponding ES (embryonic stem) cells, and make them available for development of subsequent transgenic mice. Some of these mice will go on to give their life for science in a noble manner, I guess–so maybe the analogy picks back up
The project has made tremendous progress since that paper was published, and there are a lot of knockouts you should know about if you are interested in using mouse as a model organism.
For this tip of the week we’ll explore the new portal for the International Mouse Knockout Consortium (IMKC), which used to be at the URL for the KOMP, or Knock Out Mouse Project. It appears that the groups referenced in the Mouse for All Reasons paper have now harmonized on to the knockoutmouse.org site, and use a single portal for access to the information and reagents. There are a variety of ways to search: browsing genes, specific text searching, and even a BioMart interface for the portal. This short movie takes a look at those pieces to introduce you to the site.
The announcement for this came over the MGI mailing list as this:
The IKMC web portal
The International Knockout Mouse Consortium (IKMC) has launched its official web site at www.knockoutmouse.org, formerly the URL for the Knockout Mouse Project (KOMP). This extended site, supported by the NIH and EU, now serves as the common web portal for access to information on knockout vectors, ES cells and mice available from the international high-throughput knockout projects: KOMP, EUCOMM, NorCOMM and TIGM. Stay tuned for future enhancements as the content continues to evolve. We welcome your comments and feedback. (Please email to firstname.lastname@example.org).
This site is maintained by the I-DCC and the KOMP-DCC
(http://www.knockoutmouse.org/about) . Supported by the European Union (Project number: 223592) and the National Institutes of Health (Grant number: NIH HG004074).
The International Mouse Knockout Consortium (2007). A Mouse for All Reasons Cell, 128 (1), 9-13 DOI: 10.1016/j.cell.2006.12.018