What’s the Answer? (woolly mammoth ORFs)

This week’s highlighted question was interesting to me in a couple of ways. It was a good question about the recent analysis of the woolly mammoth genome, making it a nice example of post-publication discussion. But mostly I just loved the chatter about issues and challenges around extinct organisms and their sequences. We are living the in the future now. And that’s so awesome.

Biostars is a site for asking, answering and discussing bioinformatics questions and issues. We are members of the Biostars_logo community and find it very useful. Often questions and answers arise at Biostars that are germane to our readers (end users of genomics resources). Every Thursday we will be highlighting one of those items or discussions here in this thread. You can ask questions in this thread, or you can always join in at Biostars.

Question: Where are the mammoth’s ORFs?

Not sure if anyone from the Swedish Museum of Natural History is on this forum but does anyone know any plans to process the bam files from http://www.ebi.ac.uk/ena/data/view/ERP008929 into something we can actually use for looking at protein evolution? Might Ensembl eventualy pick up the data for their pipeline Emily_Ensembl ? and/or the NCBI ? This is not the first time journal editors allow a new genome paper without the genome in question being in any usable form for biologists

“Complete Genomes Reveal Signatures of Demographic and Genetic Declines in the Woolly Mammoth”



I loved Emily’s explanation, and this part: “…mammoths have no active transcription…”. I thought to myself, well, not yet. The Plan to Turn Elephants Into Woolly Mammoths Is Already Underway. George Church and CRISPR are on the way back to the future already.