Protip: check the genome of your cell line. HeLa cells are “strikingly aberrant”

This is a paper I’ve been waiting for: the analysis of the HeLa genome. I was aware of a lot of issues with the cell lines and missing or duplicated regions from the ENCODE data that was coming along some time ago: Mining the “big data” is…fascinating. And necessary.

People may be familiar with HeLa cells even if they aren’t in biomedical research because of the great book by Rebecca Skloot: The Immortal Life of Henrietta Lacks which explored the history of these cells and the woman whose terrible cancer led to their existence.

But there were many discussions over the years about how different these cells are from actual tissues, and concerns over how representative they are for actual human research issues. Here are some:

So a new paper has been published that explores this–and it’s at the top of my reading list for later today.

Here’s the paper itself: 

Hat tip Ward Plunet via twitter:
RT @WardPlunet: Havoc in biology’s most-used human cell line: Genome of HeLa cells sequenced for the first time .

Update: A piece from one of the paper’s authors:


Landry JJM, Pyl1 PT, Rausch T, Zichner T, Tekkedil MM, Stütz AM, Jauch A, Aiyar RS, Pau G, Delhomme N, Gagneur J, Korbel JO, Huber W, & Steinmetz LM (2013). The Genomic and Transcriptomic Landscape of a HeLa Cell Line G3 : 10.1534/g3.113.005777

One thought on “Protip: check the genome of your cell line. HeLa cells are “strikingly aberrant”

  1. Pingback: HeLa genome: there’s more to this conversation | The OpenHelix Blog

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