Video Tip of the Week: PATRIC, Pathosystems Resource Integrations Center
PATRIC is a integration portal (as the name implies) of data concerning disease-causing infectious bacteria. Or to put it in their words:
PATRIC is the Bacterial Bioinformatics Resource Center, an information system designed to support the biomedical research community’s work on bacterial infectious diseases via integration of vital pathogen information with rich data and analysis tools.
We mentioned PATRIC at the beginning of the year in a SNPpets. Also, recently I was speaking with a threat abatement specialist who was lamenting the lack of coordinated data on infectious bacteria genomes. I was sure there was such a site, so we checked our blog here and voila, sure enough, exactly what they needed.
PATRIC indeed coordinates a lot of different types of data from disease-causing infectious bacteria. This includes data from all NIAID biodefense A/B/C pathogens. This includes hundreds of genomes from many isolation sources. For example, as of this writing there are nearly 500 genomes, including 57 complete, of Escherichia. In addition to genomic data, there are many other types of data including phylogenetic, host-pathogen protein-protein interactions, protein, pathways and more. One interesting feature, of many, is the disease map (for mycobacterium only right now) that shows local outbreaks and alerts. There are many tools to access and analyze this data from specialized searches to browsers.
To get a good idea of what is available at PATRIC, check out the quick intro video embedded above from the PATRIC developers. They have two other video tutorials on the feature table and identifying novel proteins you also might want to check out. Also, check out the blog for more databases and resources for infectious disease pathogens.
To cite or learn more about PATRIC, see:
Gillespie, J., Wattam, A., Cammer, S., Gabbard, J., Shukla, M., Dalay, O., Driscoll, T., Hix, D., Mane, S., Mao, C., Nordberg, E., Scott, M., Schulman, J., Snyder, E., Sullivan, D., Wang, C., Warren, A., Williams, K., Xue, T., Seung Yoo, H., Zhang, C., Zhang, Y., Will, R., Kenyon, R., & Sobral, B. (2011). PATRIC: the Comprehensive Bacterial Bioinformatics Resource with a Focus on Human Pathogenic Species Infection and Immunity, 79 (11), 4286-4298 DOI: 10.1128/IAI.00207-11