Video Tip of the Week: Biological Sequence Analysis I @ NIH

Well, more than a tip, a lecture. We haven’t done a tip today, we are in grant application process (time limiting) and this is an excellent video we’d like for more to see. Mary posted the first lecture, The Genomic Landscape circa 2012, in a series given at NIH. As the course description mentions, “The lectures are geared at the level of first year graduate students, are practical in nature, and are intended for a diverse audience.” Having watch the first and seeing most of this second, I’d say this is for 1st year graduate students and research scientists who are delving more into genomics and bioinformatics. You can view the course syllabus here and learn more about the course and topics.

Today, the second lecture in the series is up on GenomeTV and the lecture list entitled “Biological Sequence Analysis I”:

In this video he goes through the basics of sequence alignment, discussing such topics as similarity vs. homology, global vs. local alignments, scoring matrices, blast and blah. The introduction is pretty straightforward and excellent for those just starting out and for review for those of us who know these concepts but need refreshing.

It’s 90 minutes long, and worth every minute.

Quick Links:

Course page

Direct link to YouTube for this lecture:


Green, E., Guyer, M., Green, E., Guyer, M., Manolio, T., & Peterson, J. (2011). Charting a course for genomic medicine from base pairs to bedside Nature, 470 (7333), 204-213 DOI: 10.1038/nature09764